6n1i

Cryo-EM structure of NLRC4-CARD filamentCryo-EM structure of NLRC4-CARD filament

6n1i, resolution 3.58Å Show:Asymmetric Unit Biological Assembly Structural highlights 6n1i is a 16 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 6drp. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.58Å Experimental data: Check Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease NLRC4_HUMAN The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Function NLRC4_HUMAN Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity).[UniProtKB:Q3UP24]