6jc4

Crystal structure of the urease accessory protein UreF from Klebsiella pneumoniaeCrystal structure of the urease accessory protein UreF from Klebsiella pneumoniae

Structural highlights 6jc4 is a 4 chain structure with sequence from Klebsiella pneumoniae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.3Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function UREF_KLEP7 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.[HAMAP-Rule:MF_01385] Publication Abstract from PubMed Klebsiella pneumoniae is an opportunistic pathogen that mostly affects those with weakened immune systems. Urease is a vital enzyme that can hydrolyze urea to ammonia and carbon dioxide as a source of nitrogen for growth. Urease is also a K. pneumoniae virulence factor that enables survival of the bacterium under nutrient-limiting conditions. UreF, an important nickel-binding urease accessory protein, is involved in the insertion of Ni(2+) into the active site of urease. Here, the crystal structure of UreF from K. pneumoniae (KpUreF) is reported. Functional data show that KpUreF forms a stable dimer in solution. These results may provide a starting point for the design of urease inhibitors. Structural characterization of the urease accessory protein UreF from Klebsiella pneumoniae.,Liu S, Wu W, Zhao Q, Liang H, Che S, Zhang H, Liu R, Zhang Q, Bartlam M Acta Crystallogr F Struct Biol Commun. 2022 Feb 1;78(Pt 2):75-80. doi:, 10.1107/S2053230X22000474. Epub 2022 Jan 31. PMID:35102896 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Urease accessory protein 3D structures

spinqualitylabelsall models 6jc4, resolution 2.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image