6ion

The complex of C4.4A with its antibody 11H10 Fab fragmentThe complex of C4.4A with its antibody 11H10 Fab fragment

6ion is a 3 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.75Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

LYPD3_HUMAN Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression.^[1] ^[2] ^[3] ^[4]

↑ Wurfel J, Seiter S, Stassar M, Claas A, Klas R, Rosel M, Marhaba R, Savelyeva L, Schwab M, Matzku S, Zoller M. Cloning of the human homologue of the metastasis-associated rat C4.4A. Gene. 2001 Jan 10;262(1-2):35-41. PMID:11179665
↑ Smith BA, Kennedy WJ, Harnden P, Selby PJ, Trejdosiewicz LK, Southgate J. Identification of genes involved in human urothelial cell-matrix interactions: implications for the progression pathways of malignant urothelium. Cancer Res. 2001 Feb 15;61(4):1678-85. PMID:11245483
↑ Fletcher GC, Patel S, Tyson K, Adam PJ, Schenker M, Loader JA, Daviet L, Legrain P, Parekh R, Harris AL, Terrett JA. hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. Br J Cancer. 2003 Feb 24;88(4):579-85. PMID:12592373 doi:http://dx.doi.org/10.1038/sj.bjc.6600740
↑ Hansen LV, Gardsvoll H, Nielsen BS, Lund LR, Dano K, Jensen ON, Ploug M. Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor. Biochem J. 2004 Jun 15;380(Pt 3):845-57. doi: 10.1042/BJ20031478. PMID:15012588 doi:http://dx.doi.org/10.1042/BJ20031478