6h24
X-Ray Crystal Structure of the MSBI1.176 WH1 Domain, a Replication Protein Isolated from a Multiple Sclerosis PatientX-Ray Crystal Structure of the MSBI1.176 WH1 Domain, a Replication Protein Isolated from a Multiple Sclerosis Patient
Structural highlights
Publication Abstract from PubMedBovine meat and milk factors (BMMFs) are circular, single-stranded episomal DNAs that have been detected in bovine meat and milk products. BMMFs are thought to have roles in human malignant and degenerative diseases. BMMFs encode a replication initiator protein (Rep) that is actively transcribed and translated in human cells. In this study, a Rep WH1 domain encoded on a BMMF (MSBI1.176) isolated from a multiple sclerosis human brain sample was determined to 1.53 A resolution using X-ray crystallography. The overall structure of the MSBI1.176 WH1 domain was remarkably similar to other Rep structures, despite having a low (28%) amino-acid sequence identity. The MSBI1.176 WH1 domain contained elements common to other Reps, including five alpha-helices, five beta-strands and a hydrophobic pocket. These new findings suggest that the MSBI1.176 Rep might have comparable roles and functions to other known Reps of different origins. Structural analysis of a replication protein encoded by a plasmid isolated from a multiple sclerosis patient.,Kilic T, Popov AN, Burk-Korner A, Koromyslova A, Zur Hausen H, Bund T, Hansman GS Acta Crystallogr D Struct Biol. 2019 May 1;75(Pt 5):498-504. doi:, 10.1107/S2059798319003991. Epub 2019 Apr 29. PMID:31063152[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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