6f5b
Structure of ARTD2/PARP2 WGR domain bound to double stranded DNA with 5'phosphateStructure of ARTD2/PARP2 WGR domain bound to double stranded DNA with 5'phosphate
Structural highlights
FunctionPARP2_HUMAN Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. See Also |
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