Structure of ARTD2/PARP2 WGR domain bound to double stranded DNA with 5'phosphateStructure of ARTD2/PARP2 WGR domain bound to double stranded DNA with 5'phosphate

Structural highlights

6f5b is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.8Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PARP2_HUMAN Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.

See Also

6f5b, resolution 2.80Å

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