6d3h

FT_T dioxygenase with bound dichlorpropFT_T dioxygenase with bound dichlorprop

Structural highlights

6d3h is a 4 chain structure with sequence from Sphingobium herbicidovorans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.03Å
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RDPA_SPHHM Involved in the degradation of the phenoxypropionate herbicides. Catalyzes the enantiospecific cleavage of the ether bond in the herbicid R-dichlorprop ((R)-2-(2,4-dichlorophenoxy)propionate)(R-2,4-DP) and R-mecoprop ((R)-2-(4-chloro-2-methylphenoxy)propionate)(R-2,4-MCPP). It can also accept (RS)-4-chlorophenoxypropanoate, however it can only accept 2-oxoglutarate as oxygen acceptor.^[1] ^[2] ^[3]

References

↑ Muller TA, Zavodszky MI, Feig M, Kuhn LA, Hausinger RP. Structural basis for the enantiospecificities of R- and S-specific phenoxypropionate/alpha-ketoglutarate dioxygenases. Protein Sci. 2006 Jun;15(6):1356-68. doi: 10.1110/ps.052059406. PMID:16731970 doi:http://dx.doi.org/10.1110/ps.052059406
↑ Muller TA, Fleischmann T, van der Meer JR, Kohler HP. Purification and characterization of two enantioselective alpha-ketoglutarate-dependent dioxygenases, RdpA and SdpA, from Sphingomonas herbicidovorans MH. Appl Environ Microbiol. 2006 Jul;72(7):4853-61. doi: 10.1128/AEM.02758-05. PMID:16820480 doi:http://dx.doi.org/10.1128/AEM.02758-05
↑ Kohler HP. Sphingomonas herbicidovorans MH: a versatile phenoxyalkanoic acid herbicide degrader. J Ind Microbiol Biotechnol. 1999 Oct;23(4-5):336-340. doi:, 10.1038/sj/jim/2900751. PMID:11423952 doi:http://dx.doi.org/10.1038/sj/jim/2900751

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OCA

[1] Muller TA, Zavodszky MI, Feig M, Kuhn LA, Hausinger RP. Structural basis for the enantiospecificities of R- and S-specific phenoxypropionate/alpha-ketoglutarate dioxygenases. Protein Sci. 2006 Jun;15(6):1356-68. doi: 10.1110/ps.052059406. PMID:16731970 doi:http://dx.doi.org/10.1110/ps.052059406

[2] Muller TA, Fleischmann T, van der Meer JR, Kohler HP. Purification and characterization of two enantioselective alpha-ketoglutarate-dependent dioxygenases, RdpA and SdpA, from Sphingomonas herbicidovorans MH. Appl Environ Microbiol. 2006 Jul;72(7):4853-61. doi: 10.1128/AEM.02758-05. PMID:16820480 doi:http://dx.doi.org/10.1128/AEM.02758-05

[3] Kohler HP. Sphingomonas herbicidovorans MH: a versatile phenoxyalkanoic acid herbicide degrader. J Ind Microbiol Biotechnol. 1999 Oct;23(4-5):336-340. doi:, 10.1038/sj/jim/2900751. PMID:11423952 doi:http://dx.doi.org/10.1038/sj/jim/2900751

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