6a5e

Crystal structure of plant peptide RALF23 in complex with FER and LLG2Crystal structure of plant peptide RALF23 in complex with FER and LLG2

Structural highlights

6a5e is a 6 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Activity:	Non-specific serine/threonine protein kinase, with EC number 2.7.11.1
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[FERON_ARATH] Receptor-like protein kinase that mediates the female control of male gamete delivery during fertilization, including growth cessation of compatible pollen tubes ensuring a reproductive isolation barriers, by regulating MLO7 subcellular polarization upon pollen tube perception in the female gametophyte synergids. Required for cell elongation during vegetative growth, mostly in a brassinosteroids- (BR-) independent manner. Acts as an upstream regulator for the Rac/Rop-signaling pathway that controls ROS-mediated root hair development. Seems to regulate a cross-talk between brassinosteroids and ethylene signaling pathways during hypocotyl elongation. Negative regulator of brassinosteroid response in light-grown hypocotyls, but required for brassinosteroid response in etiolated seedlings. Mediates sensitivity to powdery mildew (e.g. Golovinomyces orontii). Positive regulator of auxin-promoted growth that represses the abscisic acid (ABA) signaling via the activation of ABI2 phosphatase. Required for RALF1-mediated extracellular alkalinization in a signaling pathway preventing cell expansion.^[1] ^[2] ^[3] ^[4] ^[5] ^[6] ^[7]

References

↑ Escobar-Restrepo JM, Huck N, Kessler S, Gagliardini V, Gheyselinck J, Yang WC, Grossniklaus U. The FERONIA receptor-like kinase mediates male-female interactions during pollen tube reception. Science. 2007 Aug 3;317(5838):656-60. doi: 10.1126/science.1143562. PMID:17673660 doi:http://dx.doi.org/10.1126/science.1143562
↑ Guo H, Li L, Ye H, Yu X, Algreen A, Yin Y. Three related receptor-like kinases are required for optimal cell elongation in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7648-53. doi:, 10.1073/pnas.0812346106. Epub 2009 Apr 21. PMID:19383785 doi:http://dx.doi.org/10.1073/pnas.0812346106
↑ Deslauriers SD, Larsen PB. FERONIA is a key modulator of brassinosteroid and ethylene responsiveness in Arabidopsis hypocotyls. Mol Plant. 2010 May;3(3):626-40. doi: 10.1093/mp/ssq015. Epub 2010 Apr 16. PMID:20400488 doi:http://dx.doi.org/10.1093/mp/ssq015
↑ Duan Q, Kita D, Li C, Cheung AY, Wu HM. FERONIA receptor-like kinase regulates RHO GTPase signaling of root hair development. Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17821-6. doi:, 10.1073/pnas.1005366107. Epub 2010 Sep 27. PMID:20876100 doi:http://dx.doi.org/10.1073/pnas.1005366107
↑ Kessler SA, Shimosato-Asano H, Keinath NF, Wuest SE, Ingram G, Panstruga R, Grossniklaus U. Conserved molecular components for pollen tube reception and fungal invasion. Science. 2010 Nov 12;330(6006):968-71. doi: 10.1126/science.1195211. PMID:21071669 doi:http://dx.doi.org/10.1126/science.1195211
↑ Yu F, Qian L, Nibau C, Duan Q, Kita D, Levasseur K, Li X, Lu C, Li H, Hou C, Li L, Buchanan BB, Chen L, Cheung AY, Li D, Luan S. FERONIA receptor kinase pathway suppresses abscisic acid signaling in Arabidopsis by activating ABI2 phosphatase. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14693-8. doi:, 10.1073/pnas.1212547109. Epub 2012 Aug 20. PMID:22908257 doi:http://dx.doi.org/10.1073/pnas.1212547109
↑ Haruta M, Sabat G, Stecker K, Minkoff BB, Sussman MR. A peptide hormone and its receptor protein kinase regulate plant cell expansion. Science. 2014 Jan 24;343(6169):408-11. doi: 10.1126/science.1244454. PMID:24458638 doi:http://dx.doi.org/10.1126/science.1244454

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OCA

[1] Escobar-Restrepo JM, Huck N, Kessler S, Gagliardini V, Gheyselinck J, Yang WC, Grossniklaus U. The FERONIA receptor-like kinase mediates male-female interactions during pollen tube reception. Science. 2007 Aug 3;317(5838):656-60. doi: 10.1126/science.1143562. PMID:17673660 doi:http://dx.doi.org/10.1126/science.1143562

[2] Guo H, Li L, Ye H, Yu X, Algreen A, Yin Y. Three related receptor-like kinases are required for optimal cell elongation in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7648-53. doi:, 10.1073/pnas.0812346106. Epub 2009 Apr 21. PMID:19383785 doi:http://dx.doi.org/10.1073/pnas.0812346106

[3] Deslauriers SD, Larsen PB. FERONIA is a key modulator of brassinosteroid and ethylene responsiveness in Arabidopsis hypocotyls. Mol Plant. 2010 May;3(3):626-40. doi: 10.1093/mp/ssq015. Epub 2010 Apr 16. PMID:20400488 doi:http://dx.doi.org/10.1093/mp/ssq015

[4] Duan Q, Kita D, Li C, Cheung AY, Wu HM. FERONIA receptor-like kinase regulates RHO GTPase signaling of root hair development. Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17821-6. doi:, 10.1073/pnas.1005366107. Epub 2010 Sep 27. PMID:20876100 doi:http://dx.doi.org/10.1073/pnas.1005366107

[5] Kessler SA, Shimosato-Asano H, Keinath NF, Wuest SE, Ingram G, Panstruga R, Grossniklaus U. Conserved molecular components for pollen tube reception and fungal invasion. Science. 2010 Nov 12;330(6006):968-71. doi: 10.1126/science.1195211. PMID:21071669 doi:http://dx.doi.org/10.1126/science.1195211

[6] Yu F, Qian L, Nibau C, Duan Q, Kita D, Levasseur K, Li X, Lu C, Li H, Hou C, Li L, Buchanan BB, Chen L, Cheung AY, Li D, Luan S. FERONIA receptor kinase pathway suppresses abscisic acid signaling in Arabidopsis by activating ABI2 phosphatase. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14693-8. doi:, 10.1073/pnas.1212547109. Epub 2012 Aug 20. PMID:22908257 doi:http://dx.doi.org/10.1073/pnas.1212547109

[7] Haruta M, Sabat G, Stecker K, Minkoff BB, Sussman MR. A peptide hormone and its receptor protein kinase regulate plant cell expansion. Science. 2014 Jan 24;343(6169):408-11. doi: 10.1126/science.1244454. PMID:24458638 doi:http://dx.doi.org/10.1126/science.1244454

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