5zxa

Crystal structure of fibronectin-binding protein Apa mutant from Mycobacterium tuberculosisCrystal structure of fibronectin-binding protein Apa mutant from Mycobacterium tuberculosis

Structural highlights

5zxa is a 1 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.77Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

APA_MYCTU A potent antigen in animals immunized with live bacteria, it induces a strong delayed-type hypersensitivity (DTH) in immunized animals (PubMed:10531201). Elicits a mostly Th1 type of T-cell response in healthy humans; induces IFN-gamma production from CD4(+) and CD8(+) cells (PubMed:12654810). Functions as an adhesin, binds to mouse macrophages via mannose residues (PubMed:10531201, PubMed:25359607). Might interact via host CD209 (PubMed:16092920).^[1] ^[2] ^[3] ^[4]

References

↑ Romain F, Horn C, Pescher P, Namane A, Riviere M, Puzo G, Barzu O, Marchal G. Deglycosylation of the 45/47-kilodalton antigen complex of Mycobacterium tuberculosis decreases its capacity to elicit in vivo or in vitro cellular immune responses. Infect Immun. 1999 Nov;67(11):5567-72. PMID:10531201
↑ Kumar P, Amara RR, Challu VK, Chadda VK, Satchidanandam V. The Apa protein of Mycobacterium tuberculosis stimulates gamma interferon-secreting CD4+ and CD8+ T cells from purified protein derivative-positive individuals and affords protection in a guinea pig model. Infect Immun. 2003 Apr;71(4):1929-37. doi: 10.1128/iai.71.4.1929-1937.2003. PMID:12654810 doi:http://dx.doi.org/10.1128/iai.71.4.1929-1937.2003
↑ Pitarque S, Herrmann JL, Duteyrat JL, Jackson M, Stewart GR, Lecointe F, Payre B, Schwartz O, Young DB, Marchal G, Lagrange PH, Puzo G, Gicquel B, Nigou J, Neyrolles O. Deciphering the molecular bases of Mycobacterium tuberculosis binding to the lectin DC-SIGN reveals an underestimated complexity. Biochem J. 2005 Dec 15;392(Pt 3):615-24. doi: 10.1042/BJ20050709. PMID:16092920 doi:http://dx.doi.org/10.1042/BJ20050709
↑ Esparza M, Palomares B, Garcia T, Espinosa P, Zenteno E, Mancilla R. PstS-1, the 38-kDa Mycobacterium tuberculosis glycoprotein, is an adhesin, which binds the macrophage mannose receptor and promotes phagocytosis. Scand J Immunol. 2015 Jan;81(1):46-55. doi: 10.1111/sji.12249. PMID:25359607 doi:http://dx.doi.org/10.1111/sji.12249

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OCA

[1] Romain F, Horn C, Pescher P, Namane A, Riviere M, Puzo G, Barzu O, Marchal G. Deglycosylation of the 45/47-kilodalton antigen complex of Mycobacterium tuberculosis decreases its capacity to elicit in vivo or in vitro cellular immune responses. Infect Immun. 1999 Nov;67(11):5567-72. PMID:10531201

[2] Kumar P, Amara RR, Challu VK, Chadda VK, Satchidanandam V. The Apa protein of Mycobacterium tuberculosis stimulates gamma interferon-secreting CD4+ and CD8+ T cells from purified protein derivative-positive individuals and affords protection in a guinea pig model. Infect Immun. 2003 Apr;71(4):1929-37. doi: 10.1128/iai.71.4.1929-1937.2003. PMID:12654810 doi:http://dx.doi.org/10.1128/iai.71.4.1929-1937.2003

[3] Pitarque S, Herrmann JL, Duteyrat JL, Jackson M, Stewart GR, Lecointe F, Payre B, Schwartz O, Young DB, Marchal G, Lagrange PH, Puzo G, Gicquel B, Nigou J, Neyrolles O. Deciphering the molecular bases of Mycobacterium tuberculosis binding to the lectin DC-SIGN reveals an underestimated complexity. Biochem J. 2005 Dec 15;392(Pt 3):615-24. doi: 10.1042/BJ20050709. PMID:16092920 doi:http://dx.doi.org/10.1042/BJ20050709

[4] Esparza M, Palomares B, Garcia T, Espinosa P, Zenteno E, Mancilla R. PstS-1, the 38-kDa Mycobacterium tuberculosis glycoprotein, is an adhesin, which binds the macrophage mannose receptor and promotes phagocytosis. Scand J Immunol. 2015 Jan;81(1):46-55. doi: 10.1111/sji.12249. PMID:25359607 doi:http://dx.doi.org/10.1111/sji.12249

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