5yed

Crystal structure of LokiProfilin1Crystal structure of LokiProfilin1

Structural highlights

5yed is a 1 chain structure with sequence from Lokiarchaeum sp. GC14_75. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.6Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PROF1_LOKSG Binds to actin and affects the structure of the cytoskeleton. At high concentrations inhibits spontaneous rabbit actin nucleation. This strongly suggests this archaea has a profilin-regulated actin system, and actin-type genes can be identified in this organism.^[1]

References

↑ Akil C, Robinson RC. Genomes of Asgard archaea encode profilins that regulate actin. Nature. 2018 Oct 3. pii: 10.1038/s41586-018-0548-6. doi:, 10.1038/s41586-018-0548-6. PMID:30283132 doi:http://dx.doi.org/10.1038/s41586-018-0548-6

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OCA

[1] Akil C, Robinson RC. Genomes of Asgard archaea encode profilins that regulate actin. Nature. 2018 Oct 3. pii: 10.1038/s41586-018-0548-6. doi:, 10.1038/s41586-018-0548-6. PMID:30283132 doi:http://dx.doi.org/10.1038/s41586-018-0548-6

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