5wuq

Crystal structure of SigW in complex with its anti-sigma RsiW, a zinc binding formCrystal structure of SigW in complex with its anti-sigma RsiW, a zinc binding form

Structural highlights

5wuq is a 4 chain structure with sequence from Bacillus subtilis subsp. subtilis str. 168. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.8Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SIGW_BACSU Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor (RsiW for this protein) until released by regulated membrane proteolysis. Sigma-W controls genes involved in transport processes and detoxification.^[1] ^[2]

References

↑ Helmann JD. The extracytoplasmic function (ECF) sigma factors. Adv Microb Physiol. 2002;46:47-110. PMID:12073657
↑ Jung YG, Cho YB, Kim MS, Yoo JS, Hong SH, Roe JH. Determinants of redox sensitivity in RsrA, a zinc-containing anti-sigma factor for regulating thiol oxidative stress response. Nucleic Acids Res. 2011 Sep 1;39(17):7586-97. doi: 10.1093/nar/gkr477. Epub 2011 , Jun 17. PMID:21685450 doi:http://dx.doi.org/10.1093/nar/gkr477

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OCA

[1] Helmann JD. The extracytoplasmic function (ECF) sigma factors. Adv Microb Physiol. 2002;46:47-110. PMID:12073657

[2] Jung YG, Cho YB, Kim MS, Yoo JS, Hong SH, Roe JH. Determinants of redox sensitivity in RsrA, a zinc-containing anti-sigma factor for regulating thiol oxidative stress response. Nucleic Acids Res. 2011 Sep 1;39(17):7586-97. doi: 10.1093/nar/gkr477. Epub 2011 , Jun 17. PMID:21685450 doi:http://dx.doi.org/10.1093/nar/gkr477

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