5ua4

Crystal structure of A179L:Bid BH3 complexCrystal structure of A179L:Bid BH3 complex

Structural highlights

5ua4 is a 2 chain structure with sequence from African swine fever virus and Sus scrofa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.6Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ARBH_ASFB7 Suppresses apoptosis in host cell and thus facilitates production of progeny virions (PubMed:9123849, PubMed:18329683). Has the ability to potentially bind to all the members of the proapoptotic Bcl-2 family (PubMed:28053104, PubMed:18329683).^[1] ^[2] ^[3]

References

↑ Galindo I, Hernaez B, Diaz-Gil G, Escribano JM, Alonso C. A179L, a viral Bcl-2 homologue, targets the core Bcl-2 apoptotic machinery and its upstream BH3 activators with selective binding restrictions for Bid and Noxa. Virology. 2008 Jun 5;375(2):561-72. doi: 10.1016/j.virol.2008.01.050. Epub 2008, Mar 10. PMID:18329683 doi:http://dx.doi.org/10.1016/j.virol.2008.01.050
↑ Banjara S, Caria S, Dixon LK, Hinds MG, Kvansakul M. Structural insight into African Swine Fever virus A179L mediated inhibition of apoptosis. J Virol. 2017 Jan 4. pii: JVI.02228-16. doi: 10.1128/JVI.02228-16. PMID:28053104 doi:http://dx.doi.org/10.1128/JVI.02228-16
↑ Revilla Y, Cebrian A, Baixeras E, Martinez C, Vinuela E, Salas ML. Inhibition of apoptosis by the African swine fever virus Bcl-2 homologue: role of the BH1 domain. Virology. 1997 Feb 17;228(2):400-4. doi: 10.1006/viro.1996.8395. PMID:9123849 doi:http://dx.doi.org/10.1006/viro.1996.8395

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OCA

[1] Galindo I, Hernaez B, Diaz-Gil G, Escribano JM, Alonso C. A179L, a viral Bcl-2 homologue, targets the core Bcl-2 apoptotic machinery and its upstream BH3 activators with selective binding restrictions for Bid and Noxa. Virology. 2008 Jun 5;375(2):561-72. doi: 10.1016/j.virol.2008.01.050. Epub 2008, Mar 10. PMID:18329683 doi:http://dx.doi.org/10.1016/j.virol.2008.01.050

[2] Banjara S, Caria S, Dixon LK, Hinds MG, Kvansakul M. Structural insight into African Swine Fever virus A179L mediated inhibition of apoptosis. J Virol. 2017 Jan 4. pii: JVI.02228-16. doi: 10.1128/JVI.02228-16. PMID:28053104 doi:http://dx.doi.org/10.1128/JVI.02228-16

[3] Revilla Y, Cebrian A, Baixeras E, Martinez C, Vinuela E, Salas ML. Inhibition of apoptosis by the African swine fever virus Bcl-2 homologue: role of the BH1 domain. Virology. 1997 Feb 17;228(2):400-4. doi: 10.1006/viro.1996.8395. PMID:9123849 doi:http://dx.doi.org/10.1006/viro.1996.8395

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