5u57

Psf4 in complex with Fe2+ and (S)-2-HPPPsf4 in complex with Fe2+ and (S)-2-HPP

Structural highlights

5u57 is a 4 chain structure with sequence from Pseudomonas syringae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.73Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HPPE_PSESX Non-heme-dependent dioxygenase that catalyzes the oxidative epoxidation of (S)-2-hydroxypropylphosphonate into (1R,2S)-epoxypropylphosphonate, the final step in the biosynthesis of fosfomycin antibiotic.^[1]

References

↑ Munos JW, Moon SJ, Mansoorabadi SO, Chang W, Hong L, Yan F, Liu A, Liu HW. Purification and characterization of the epoxidase catalyzing the formation of fosfomycin from Pseudomonas syringae. Biochemistry. 2008 Aug 19;47(33):8726-35. doi: 10.1021/bi800877v. Epub 2008 Jul, 26. PMID:18656958 doi:http://dx.doi.org/10.1021/bi800877v

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OCA

[1] Munos JW, Moon SJ, Mansoorabadi SO, Chang W, Hong L, Yan F, Liu A, Liu HW. Purification and characterization of the epoxidase catalyzing the formation of fosfomycin from Pseudomonas syringae. Biochemistry. 2008 Aug 19;47(33):8726-35. doi: 10.1021/bi800877v. Epub 2008 Jul, 26. PMID:18656958 doi:http://dx.doi.org/10.1021/bi800877v

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