5t96

Crystal structure of the infectious salmon anemia virus (ISAV) HE viral receptor complexCrystal structure of the infectious salmon anemia virus (ISAV) HE viral receptor complex

Structural highlights

5t96 is a 6 chain structure with sequence from Salmon isavirus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2Å
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q9J0Y0_9ORTO

Publication Abstract from PubMed

Orthomyxoviruses are an important family of RNA viruses, which include the various influenza viruses. Despite global efforts to eradicate orthomyxoviral pathogens, these infections remain pervasive. One such orthomyxovirus, infectious salmon anemia virus (ISAV), spreads easily throughout farmed and wild salmonids, constituting a significant economic burden. ISAV entry requires the interplay of the virion-attached hemagglutinin-esterase and fusion glycoproteins. Preventing infections will rely on improved understanding of ISAV entry. Here, we present the crystal structures of ISAV hemagglutinin-esterase unbound and complexed with receptor. Several distinctive features observed in ISAV HE are not seen in any other viral glycoprotein. The structures reveal a unique mode of receptor binding that is dependent on the oligomeric assembly of hemagglutinin-esterase. Importantly, ISAV hemagglutinin-esterase receptor engagement does not initiate conformational rearrangements, suggesting a distinct viral entry mechanism. This work improves our understanding of ISAV pathogenesis and expands our knowledge on the overall diversity of viral glycoprotein-mediated entry mechanisms. Finally, it provides an atomic-resolution model of the primary neutralizing antigen critical for vaccine development.

Structure of the infectious salmon anemia virus receptor complex illustrates a unique binding strategy for attachment.,Cook JD, Sultana A, Lee JE Proc Natl Acad Sci U S A. 2017 Mar 20. pii: 201617993. doi:, 10.1073/pnas.1617993114. PMID:28320973^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Cook JD, Sultana A, Lee JE. Structure of the infectious salmon anemia virus receptor complex illustrates a unique binding strategy for attachment. Proc Natl Acad Sci U S A. 2017 Mar 20. pii: 201617993. doi:, 10.1073/pnas.1617993114. PMID:28320973 doi:http://dx.doi.org/10.1073/pnas.1617993114

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OCA

[1] Cook JD, Sultana A, Lee JE. Structure of the infectious salmon anemia virus receptor complex illustrates a unique binding strategy for attachment. Proc Natl Acad Sci U S A. 2017 Mar 20. pii: 201617993. doi:, 10.1073/pnas.1617993114. PMID:28320973 doi:http://dx.doi.org/10.1073/pnas.1617993114

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