5svc

Mechanism of ATP-Dependent Acetone Carboxylation, Acetone Carboxylase nucleotide-free structureMechanism of ATP-Dependent Acetone Carboxylation, Acetone Carboxylase nucleotide-free structure

Structural highlights

5svc is a 6 chain structure with sequence from Xanthobacter autotrophicus Py2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.7Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ACXA_XANP2 Catalyzes the carboxylation of acetone to form acetoacetate. Has a reduced activity on butanone, and no activity on 2-pentatone, 3-pentatone, 2-hexanone, chloroacetone, pyruvate, phosphoenolpyruvate, acetaldehyde, propionaldehyde and propylene oxide.^[1]

References

↑ Sluis MK, Ensign SA. Purification and characterization of acetone carboxylase from Xanthobacter strain Py2. Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8456-61. PMID:9237998

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OCA

[1] Sluis MK, Ensign SA. Purification and characterization of acetone carboxylase from Xanthobacter strain Py2. Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8456-61. PMID:9237998

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