5j0a

Crystal structure of PDZ-binding kinaseCrystal structure of PDZ-binding kinase

Structural highlights

5j0a is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.74Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TOPK_HUMAN Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.^[1] ^[2]

References

↑ Abe Y, Matsumoto S, Kito K, Ueda N. Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells. J Biol Chem. 2000 Jul 14;275(28):21525-31. PMID:10781613 doi:http://dx.doi.org/10.1074/jbc.M909629199
↑ Nandi AK, Ford T, Fleksher D, Neuman B, Rapoport AP. Attenuation of DNA damage checkpoint by PBK, a novel mitotic kinase, involves protein-protein interaction with tumor suppressor p53. Biochem Biophys Res Commun. 2007 Jun 22;358(1):181-8. Epub 2007 Apr 30. PMID:17482142 doi:http://dx.doi.org/S0006-291X(07)00824-8

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Abe Y, Matsumoto S, Kito K, Ueda N. Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells. J Biol Chem. 2000 Jul 14;275(28):21525-31. PMID:10781613 doi:http://dx.doi.org/10.1074/jbc.M909629199

[2] Nandi AK, Ford T, Fleksher D, Neuman B, Rapoport AP. Attenuation of DNA damage checkpoint by PBK, a novel mitotic kinase, involves protein-protein interaction with tumor suppressor p53. Biochem Biophys Res Commun. 2007 Jun 22;358(1):181-8. Epub 2007 Apr 30. PMID:17482142 doi:http://dx.doi.org/S0006-291X(07)00824-8

[1]

[2]