5hl1

Crystal structure of glutaminase C in complex with inhibitor CB-839Crystal structure of glutaminase C in complex with inhibitor CB-839

Structural highlights

5hl1 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.4Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GLSK_HUMAN Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity.

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OCA

5hl1

Crystal structure of glutaminase C in complex with inhibitor CB-839Crystal structure of glutaminase C in complex with inhibitor CB-839

Structural highlights

Function

See Also

Contents

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