Proteopedia

5hh7

crystal structure of Arabidopsis ORC1b BAH-PHD cassette in complex with unmodified H3 peptidecrystal structure of Arabidopsis ORC1b BAH-PHD cassette in complex with unmodified H3 peptide

Structural highlights

5hh7 is a 2 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.901Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ORC1B_ARATH Essential protein required for ovules fertilization (PubMed:15634699, PubMed:19171893). Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication (By similarity). H3K4me3 effector that regulates positively the transcription of a subset of genes (PubMed:19171893).[UniProtKB:P54784][1] [2]

References

  1. ↑ Pagnussat GC, Yu HJ, Ngo QA, Rajani S, Mayalagu S, Johnson CS, Capron A, Xie LF, Ye D, Sundaresan V. Genetic and molecular identification of genes required for female gametophyte development and function in Arabidopsis. Development. 2005 Feb;132(3):603-14. Epub 2005 Jan 5. PMID:15634699 doi:http://dx.doi.org/dev.01595
  2. ↑ de la Paz Sanchez M, Gutierrez C. Arabidopsis ORC1 is a PHD-containing H3K4me3 effector that regulates transcription. Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):2065-70. doi:, 10.1073/pnas.0811093106. Epub 2009 Jan 26. PMID:19171893 doi:http://dx.doi.org/10.1073/pnas.0811093106

5hh7, resolution 1.90Å

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OCA
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