5eqb

Crystal structure of lanosterol 14-alpha demethylase with intact transmembrane domain bound to itraconazoleCrystal structure of lanosterol 14-alpha demethylase with intact transmembrane domain bound to itraconazole

Structural highlights 5eqb is a 1 chain structure with sequence from Saccharomyces cerevisiae S288C. This structure supersedes the now removed PDB entry 4k0f. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.19Å Ligands: , Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function CP51_YEAST Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. See Also Cytochrome P450 3D structures

spinqualitylabelsall models 5eqb, resolution 2.19Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image