5dxx

Crystal structure of Dbr2Crystal structure of Dbr2

Structural highlights

5dxx is a 1 chain structure with sequence from Artemisia annua. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.45Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DBR2_ARTAN Involved in the biosynthesis of the antimalarial endoperoxide artemisinin by catalyzing the double bond reduction of (11R)-dihydroartemisinic aldehyde to produce artemisinic aldehyde. Also able to reduce artemisinic alcohol and artemisinic acid to a lesser extent.^[1]

References

↑ Zhang Y, Teoh KH, Reed DW, Maes L, Goossens A, Olson DJ, Ross AR, Covello PS. The molecular cloning of artemisinic aldehyde Delta11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua. J Biol Chem. 2008 Aug 1;283(31):21501-8. doi: 10.1074/jbc.M803090200. Epub 2008, May 21. PMID:18495659 doi:http://dx.doi.org/10.1074/jbc.M803090200

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OCA

[1] Zhang Y, Teoh KH, Reed DW, Maes L, Goossens A, Olson DJ, Ross AR, Covello PS. The molecular cloning of artemisinic aldehyde Delta11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua. J Biol Chem. 2008 Aug 1;283(31):21501-8. doi: 10.1074/jbc.M803090200. Epub 2008, May 21. PMID:18495659 doi:http://dx.doi.org/10.1074/jbc.M803090200

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