Proteopedia

4oob

Crystal structure of HtdX(Rv0241c) from Mycobacterium tuberculosisCrystal structure of HtdX(Rv0241c) from Mycobacterium tuberculosis

Structural highlights

4oob is a 1 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HTDX_MYCTU Shows trans-enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydratase activity (PubMed:19136596, PubMed:20511508). Displays a broad chain length specificity, with a predilection for the C8 to C12 substrates (PubMed:20511508).[1] [2]

References

  1. ↑ Gurvitz A, Hiltunen JK, Kastaniotis AJ. Heterologous expression of mycobacterial proteins in Saccharomyces cerevisiae reveals two physiologically functional 3-hydroxyacyl-thioester dehydratases, HtdX and HtdY, in addition to HadABC and HtdZ. J Bacteriol. 2009 Apr;191(8):2683-90. doi: 10.1128/JB.01046-08. Epub 2009 Jan 9. PMID:19136596 doi:http://dx.doi.org/10.1128/JB.01046-08
  2. ↑ Sacco E, Slama N, Backbro K, Parish T, Laval F, Daffe M, Eynard N, Quemard A. Revisiting the assignment of Rv0241c to fatty acid synthase type II of Mycobacterium tuberculosis. J Bacteriol. 2010 Aug;192(15):4037-44. doi: 10.1128/JB.00386-10. Epub 2010 May , 28. PMID:20511508 doi:http://dx.doi.org/10.1128/JB.00386-10

4oob, resolution 2.30Å

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OCA
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