Crystal structure of Zebrafish ALKBH5 in complex with alpha-ketoglutarateCrystal structure of Zebrafish ALKBH5 in complex with alpha-ketoglutarate

Structural highlights

4npl is a 2 chain structure with sequence from Danio rerio. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.651Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ALKB5_DANRE Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).

See Also

4npl, resolution 1.65Å

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