4nc6

Tbc domain of human rab gtpase-activating protein 1Tbc domain of human rab gtpase-activating protein 1

Structural highlights

4nc6 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.8Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RBGP1_HUMAN May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition.^[1] ^[2]

References

↑ Cuif MH, Possmayer F, Zander H, Bordes N, Jollivet F, Couedel-Courteille A, Janoueix-Lerosey I, Langsley G, Bornens M, Goud B. Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome. EMBO J. 1999 Apr 1;18(7):1772-82. PMID:10202141 doi:http://dx.doi.org/10.1093/emboj/18.7.1772
↑ Miserey-Lenkei S, Couedel-Courteille A, Del Nery E, Bardin S, Piel M, Racine V, Sibarita JB, Perez F, Bornens M, Goud B. A role for the Rab6A' GTPase in the inactivation of the Mad2-spindle checkpoint. EMBO J. 2006 Jan 25;25(2):278-89. Epub 2006 Jan 5. PMID:16395330 doi:http://dx.doi.org/7600929

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OCA

[1] Cuif MH, Possmayer F, Zander H, Bordes N, Jollivet F, Couedel-Courteille A, Janoueix-Lerosey I, Langsley G, Bornens M, Goud B. Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome. EMBO J. 1999 Apr 1;18(7):1772-82. PMID:10202141 doi:http://dx.doi.org/10.1093/emboj/18.7.1772

[2] Miserey-Lenkei S, Couedel-Courteille A, Del Nery E, Bardin S, Piel M, Racine V, Sibarita JB, Perez F, Bornens M, Goud B. A role for the Rab6A' GTPase in the inactivation of the Mad2-spindle checkpoint. EMBO J. 2006 Jan 25;25(2):278-89. Epub 2006 Jan 5. PMID:16395330 doi:http://dx.doi.org/7600929

[1]

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