4nb5

Crystal Structure of a transcriptional regulatorCrystal Structure of a transcriptional regulator

Structural highlights

4nb5 is a 4 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.641Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MMPR5_MYCTU Controls the expression level of the Mmps2-MmpL2, MmpS4-MmpL4, and MmpS5-MmpL5 transport systems. Also controls its own expression. Acts by binding directly to the promoter regions.^[1] ^[2] ^[3]

References

↑ Milano A, Pasca MR, Provvedi R, Lucarelli AP, Manina G, Ribeiro AL, Manganelli R, Riccardi G. Azole resistance in Mycobacterium tuberculosis is mediated by the MmpS5-MmpL5 efflux system. Tuberculosis (Edinb). 2009 Jan;89(1):84-90. doi: 10.1016/j.tube.2008.08.003. Epub , 2008 Oct 11. PMID:18851927 doi:http://dx.doi.org/10.1016/j.tube.2008.08.003
↑ Hartkoorn RC, Uplekar S, Cole ST. Cross-resistance between clofazimine and bedaquiline through upregulation of MmpL5 in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2014 May;58(5):2979-81. doi: 10.1128/AAC.00037-14. , Epub 2014 Mar 3. PMID:24590481 doi:http://dx.doi.org/10.1128/AAC.00037-14
↑ Radhakrishnan A, Kumar N, Wright CC, Chou TH, Tringides ML, Bolla JR, Lei HT, Rajashankar K, Su CC, Purdy GE, Yu EW. Crystal structure of the transcriptional regulator Rv0678 of Mycobacterium tuberculosis. J Biol Chem. 2014 Apr 15. PMID:24737322 doi:http://dx.doi.org/10.1074/jbc.M113.538959

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OCA

[1] Milano A, Pasca MR, Provvedi R, Lucarelli AP, Manina G, Ribeiro AL, Manganelli R, Riccardi G. Azole resistance in Mycobacterium tuberculosis is mediated by the MmpS5-MmpL5 efflux system. Tuberculosis (Edinb). 2009 Jan;89(1):84-90. doi: 10.1016/j.tube.2008.08.003. Epub , 2008 Oct 11. PMID:18851927 doi:http://dx.doi.org/10.1016/j.tube.2008.08.003

[2] Hartkoorn RC, Uplekar S, Cole ST. Cross-resistance between clofazimine and bedaquiline through upregulation of MmpL5 in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2014 May;58(5):2979-81. doi: 10.1128/AAC.00037-14. , Epub 2014 Mar 3. PMID:24590481 doi:http://dx.doi.org/10.1128/AAC.00037-14

[3] Radhakrishnan A, Kumar N, Wright CC, Chou TH, Tringides ML, Bolla JR, Lei HT, Rajashankar K, Su CC, Purdy GE, Yu EW. Crystal structure of the transcriptional regulator Rv0678 of Mycobacterium tuberculosis. J Biol Chem. 2014 Apr 15. PMID:24737322 doi:http://dx.doi.org/10.1074/jbc.M113.538959

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