4ka8

Structure of Organellar OligoPeptidaseStructure of Organellar OligoPeptidase

Structural highlights

4ka8 is a 1 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.9Å
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

OOPDA_ARATH Oligopeptidase degrading short peptides from 8 to 23 amino acid residues. Plays a role in the degradation of transit peptides and of peptides derived from other proteolytic events. Does not exhibit a strict cleavage pattern. Binds salicylic acid.^[1] ^[2]

References

↑ Moreau M, Westlake T, Zampogna G, Popescu G, Tian M, Noutsos C, Popescu S. The Arabidopsis oligopeptidases TOP1 and TOP2 are salicylic acid targets that modulate SA-mediated signaling and the immune response. Plant J. 2013 Nov;76(4):603-14. doi: 10.1111/tpj.12320. Epub 2013 Oct 18. PMID:24004003 doi:http://dx.doi.org/10.1111/tpj.12320
↑ Kmiec B, Teixeira PF, Berntsson RP, Murcha MW, Branca RM, Radomiljac JD, Regberg J, Svensson LM, Bakali A, Langel U, Lehtio J, Whelan J, Stenmark P, Glaser E. Organellar oligopeptidase (OOP) provides a complementary pathway for targeting peptide degradation in mitochondria and chloroplasts. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3761-9. doi:, 10.1073/pnas.1307637110. Epub 2013 Sep 16. PMID:24043784 doi:http://dx.doi.org/10.1073/pnas.1307637110

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OCA

[1] Moreau M, Westlake T, Zampogna G, Popescu G, Tian M, Noutsos C, Popescu S. The Arabidopsis oligopeptidases TOP1 and TOP2 are salicylic acid targets that modulate SA-mediated signaling and the immune response. Plant J. 2013 Nov;76(4):603-14. doi: 10.1111/tpj.12320. Epub 2013 Oct 18. PMID:24004003 doi:http://dx.doi.org/10.1111/tpj.12320

[2] Kmiec B, Teixeira PF, Berntsson RP, Murcha MW, Branca RM, Radomiljac JD, Regberg J, Svensson LM, Bakali A, Langel U, Lehtio J, Whelan J, Stenmark P, Glaser E. Organellar oligopeptidase (OOP) provides a complementary pathway for targeting peptide degradation in mitochondria and chloroplasts. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3761-9. doi:, 10.1073/pnas.1307637110. Epub 2013 Sep 16. PMID:24043784 doi:http://dx.doi.org/10.1073/pnas.1307637110

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