4hnt

crystal structure of F403A mutant of S. aureus Pyruvate carboxylasecrystal structure of F403A mutant of S. aureus Pyruvate carboxylase

Structural highlights

4hnt is a 4 chain structure with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.8Å
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PYC_STAAM Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.^[1] ^[2]

References

↑ Yu LP, Xiang S, Lasso G, Gil D, Valle M, Tong L. A symmetrical tetramer for S. aureus pyruvate carboxylase in complex with coenzyme A. Structure. 2009 Jun 10;17(6):823-32. PMID:19523900 doi:10.1016/j.str.2009.04.008
↑ Yu LP, Chou CY, Choi PH, Tong L. Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis. Biochemistry. 2013 Jan 9. PMID:23286247 doi:http://dx.doi.org/10.1021/bi301294d

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OCA

[1] Yu LP, Xiang S, Lasso G, Gil D, Valle M, Tong L. A symmetrical tetramer for S. aureus pyruvate carboxylase in complex with coenzyme A. Structure. 2009 Jun 10;17(6):823-32. PMID:19523900 doi:10.1016/j.str.2009.04.008

[2] Yu LP, Chou CY, Choi PH, Tong L. Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis. Biochemistry. 2013 Jan 9. PMID:23286247 doi:http://dx.doi.org/10.1021/bi301294d

[1]

[2]