4fbt
Dpo4 post-insertion complex with the N-(deoxyguanosin-8-yl)-1-aminopyrene lesionDpo4 post-insertion complex with the N-(deoxyguanosin-8-yl)-1-aminopyrene lesion
Structural highlights
FunctionDPO4_SACS2 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis. See Also |
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