4d7y

Crystal structure of mouse C1QL1 globular domainCrystal structure of mouse C1QL1 globular domain

Structural highlights

4d7y is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.44Å
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

C1QRF_MOUSE May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses.^[1]

Publication Abstract from PubMed

Neuronal networks are dynamically modified by selective synapse pruning during development and adulthood. However, how certain connections win the competition with others and are subsequently maintained is not fully understood. Here, we show that C1ql1, a member of the C1q family of proteins, is provided by climbing fibers (CFs) and serves as a crucial anterograde signal to determine and maintain the single-winner CF in the mouse cerebellum throughout development and adulthood. C1ql1 specifically binds to the brain-specific angiogenesis inhibitor 3 (Bai3), which is a member of the cell-adhesion G-protein-coupled receptor family and expressed on postsynaptic Purkinje cells. C1ql1-Bai3 signaling is required for motor learning but not for gross motor performance or coordination. Because related family members of C1ql1 and Bai3 are expressed in various brain regions, the mechanism described here likely applies to synapse formation, maintenance, and function in multiple neuronal circuits essential for important brain functions.

Anterograde c1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum.,Kakegawa W, Mitakidis N, Miura E, Abe M, Matsuda K, Takeo YH, Kohda K, Motohashi J, Takahashi A, Nagao S, Muramatsu S, Watanabe M, Sakimura K, Aricescu AR, Yuzaki M Neuron. 2015 Jan 21;85(2):316-29. doi: 10.1016/j.neuron.2014.12.020. PMID:25611509^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Bolliger MF, Martinelli DC, Sudhof TC. The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2534-9. doi: 10.1073/pnas.1019577108., Epub 2011 Jan 24. PMID:21262840 doi:http://dx.doi.org/10.1073/pnas.1019577108
↑ Kakegawa W, Mitakidis N, Miura E, Abe M, Matsuda K, Takeo YH, Kohda K, Motohashi J, Takahashi A, Nagao S, Muramatsu S, Watanabe M, Sakimura K, Aricescu AR, Yuzaki M. Anterograde c1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum. Neuron. 2015 Jan 21;85(2):316-29. doi: 10.1016/j.neuron.2014.12.020. PMID:25611509 doi:http://dx.doi.org/10.1016/j.neuron.2014.12.020

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OCA

[1] Bolliger MF, Martinelli DC, Sudhof TC. The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2534-9. doi: 10.1073/pnas.1019577108., Epub 2011 Jan 24. PMID:21262840 doi:http://dx.doi.org/10.1073/pnas.1019577108

[2] Kakegawa W, Mitakidis N, Miura E, Abe M, Matsuda K, Takeo YH, Kohda K, Motohashi J, Takahashi A, Nagao S, Muramatsu S, Watanabe M, Sakimura K, Aricescu AR, Yuzaki M. Anterograde c1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum. Neuron. 2015 Jan 21;85(2):316-29. doi: 10.1016/j.neuron.2014.12.020. PMID:25611509 doi:http://dx.doi.org/10.1016/j.neuron.2014.12.020

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