4c1w
Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase complexed with 3'-sialyllactoseCarbohydrate binding domain from Streptococcus pneumoniae NanA sialidase complexed with 3'-sialyllactose
Structural highlights
FunctionPublication Abstract from PubMedThere is a need for new approaches for the control of influenza given the burden caused by annual seasonal outbreaks, the emergence of viruses with pandemic potential, and the development of resistance to current antiviral drugs. We show that multivalent biologics, engineered using carbohydrate-binding modules specific for sialic acid, mask the cell-surface receptor recognized by the influenza virus and protect mice from a lethal challenge with 2009 pandemic H1N1 influenza virus. The most promising biologic protects mice when given as a single 1-mug intranasal dose 7 d in advance of viral challenge. There also is sufficient virus replication to establish an immune response, potentially protecting the animal from future exposure to the virus. Furthermore, the biologics appear to stimulate inflammatory mediators, and this stimulation may contribute to their protective ability. Our results suggest that this host-targeted approach could provide a front-line prophylactic that has the potential to protect against any current and future influenza virus and possibly against other respiratory pathogens that use sialic acid as a receptor. Prevention of influenza by targeting host receptors using engineered proteins.,Connaris H, Govorkova EA, Ligertwood Y, Dutia BM, Yang L, Tauber S, Taylor MA, Alias N, Hagan R, Nash AA, Webster RG, Taylor GL Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6401-6. doi:, 10.1073/pnas.1404205111. Epub 2014 Apr 14. PMID:24733924[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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