4af8

The structural basis for metacaspase substrate specificity and activationThe structural basis for metacaspase substrate specificity and activation

4af8 is a 1 chain structure with sequence from Trypanosoma brucei. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.4Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

MCA2_TRYB2 Cysteine protease that cleaves specifically after arginine or lysine residues.^[1] ^[2]

↑ Moss CX, Westrop GD, Juliano L, Coombs GH, Mottram JC. Metacaspase 2 of Trypanosoma brucei is a calcium-dependent cysteine peptidase active without processing. FEBS Lett. 2007 Dec 11;581(29):5635-9. PMID:18005666 doi:10.1016/j.febslet.2007.11.009
↑ Machado MF, Marcondes MF, Juliano MA, McLuskey K, Mottram JC, Moss CX, Juliano L, Oliveira V. Substrate specificity and the effect of calcium on Trypanosoma brucei metacaspase 2. FEBS J. 2013 Jun;280(11):2608-21. PMID:23506317 doi:10.1111/febs.12248