3u5u

Structures of Alkaloid Biosynthetic Glucosidases Decode Substrate SpecificityStructures of Alkaloid Biosynthetic Glucosidases Decode Substrate Specificity

Structural highlights

3u5u is a 2 chain structure with sequence from Rauvolfia serpentina. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.2Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RG1_RAUSE Glucosidase specifically involved in alkaloid biosynthesis leading to the accumulation of several alkaloids, including ajmaline, an important plant-derived pharmaceutical used in the treatment of heart disorders.^[1]

References

↑ Warzecha H, Gerasimenko I, Kutchan TM, Stockigt J. Molecular cloning and functional bacterial expression of a plant glucosidase specifically involved in alkaloid biosynthesis. Phytochemistry. 2000 Aug;54(7):657-66. doi: 10.1016/s0031-9422(00)00175-8. PMID:10975500 doi:http://dx.doi.org/10.1016/s0031-9422(00)00175-8

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OCA

[1] Warzecha H, Gerasimenko I, Kutchan TM, Stockigt J. Molecular cloning and functional bacterial expression of a plant glucosidase specifically involved in alkaloid biosynthesis. Phytochemistry. 2000 Aug;54(7):657-66. doi: 10.1016/s0031-9422(00)00175-8. PMID:10975500 doi:http://dx.doi.org/10.1016/s0031-9422(00)00175-8

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