3tm5

Crystal structure of Trm14 from Pyrococcus furiosus in complex with sinefunginCrystal structure of Trm14 from Pyrococcus furiosus in complex with sinefungin

Structural highlights

3tm5 is a 2 chain structure with sequence from Pyrococcus furiosus DSM 3638. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.27Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TRM14_PYRFU S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the methylation of the guanosine nucleotide at position 6 (m2G6) in tRNA(Phe).^[1] ^[2]

References

↑ Roovers M, Oudjama Y, Fislage M, Bujnicki JM, Versees W, Droogmans L. The open reading frame TTC1157 of Thermus thermophilus HB27 encodes the methyltransferase forming N(2)-methylguanosine at position 6 in tRNA. RNA. 2012 Apr;18(4):815-24. Epub 2012 Feb 15. PMID:22337946 doi:10.1261/rna.030411.111
↑ Fislage M, Roovers M, Tuszynska I, Bujnicki JM, Droogmans L, Versees W. Crystal structures of the tRNA:m2G6 methyltransferase Trm14/TrmN from two domains of life. Nucleic Acids Res. 2012 Feb 22. PMID:22362751 doi:10.1093/nar/gks163

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OCA

[1] Roovers M, Oudjama Y, Fislage M, Bujnicki JM, Versees W, Droogmans L. The open reading frame TTC1157 of Thermus thermophilus HB27 encodes the methyltransferase forming N(2)-methylguanosine at position 6 in tRNA. RNA. 2012 Apr;18(4):815-24. Epub 2012 Feb 15. PMID:22337946 doi:10.1261/rna.030411.111

[2] Fislage M, Roovers M, Tuszynska I, Bujnicki JM, Droogmans L, Versees W. Crystal structures of the tRNA:m2G6 methyltransferase Trm14/TrmN from two domains of life. Nucleic Acids Res. 2012 Feb 22. PMID:22362751 doi:10.1093/nar/gks163

[1]

[2]

3tm5

Crystal structure of Trm14 from Pyrococcus furiosus in complex with sinefunginCrystal structure of Trm14 from Pyrococcus furiosus in complex with sinefungin

Structural highlights

Function

See Also

References

Contents

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