3s60

Structure of the cyanobacterial Oscillatoria Agardhii Agglutinin (OAA) in free state obtained at 25 degree CelsiusStructure of the cyanobacterial Oscillatoria Agardhii Agglutinin (OAA) in free state obtained at 25 degree Celsius

Structural highlights

3s60 is a 1 chain structure with sequence from Planktothrix agardhii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.6Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LEC1_PLAAG Lectin specific for high mannose N-glycans, recognizes the branched moiety of these glycans. Does not recognize other types of N-glycans or monosaccharides. Agglutinates trypsin-treated rabbit erythrocytes. Does not require divalent cations for activity. Inhibits HIV replication in MT4 cells with an EC(50) of 45 nM. Binds to the HIV envelope glycoprotein gp120.^[1] ^[2]

References

↑ Sato Y, Murakami M, Miyazawa K, Hori K. Purification and characterization of a novel lectin from a freshwater cyanobacterium, Oscillatoria agardhii. Comp Biochem Physiol B Biochem Mol Biol. 2000 Feb;125(2):169-77. PMID:10817903 doi:10.1016/s0305-0491(99)00164-9
↑ Sato Y, Okuyama S, Hori K. Primary structure and carbohydrate binding specificity of a potent anti-HIV lectin isolated from the filamentous cyanobacterium Oscillatoria agardhii. J Biol Chem. 2007 Apr 13;282(15):11021-9. Epub 2007 Feb 21. PMID:17314091 doi:10.1074/jbc.M701252200

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OCA

[1] Sato Y, Murakami M, Miyazawa K, Hori K. Purification and characterization of a novel lectin from a freshwater cyanobacterium, Oscillatoria agardhii. Comp Biochem Physiol B Biochem Mol Biol. 2000 Feb;125(2):169-77. PMID:10817903 doi:10.1016/s0305-0491(99)00164-9

[2] Sato Y, Okuyama S, Hori K. Primary structure and carbohydrate binding specificity of a potent anti-HIV lectin isolated from the filamentous cyanobacterium Oscillatoria agardhii. J Biol Chem. 2007 Apr 13;282(15):11021-9. Epub 2007 Feb 21. PMID:17314091 doi:10.1074/jbc.M701252200

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