3q91

Crystal Structure of Human Uridine Diphosphate Glucose Pyrophosphatase (NUDT14)Crystal Structure of Human Uridine Diphosphate Glucose Pyrophosphatase (NUDT14)

Structural highlights

3q91 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.7Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NUD14_HUMAN Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.

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OCA