3q7r

1.6A resolution structure of the ChxR receiver domain from Chlamydia trachomatis1.6A resolution structure of the ChxR receiver domain from Chlamydia trachomatis

Structural highlights

3q7r is a 2 chain structure with sequence from Chlamydia trachomatis 434/Bu. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.6Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CHXR_CHLT2 May be a global positive regulator of transcription (PubMed:21057008). Binds a cis-acting element of its own promoter DNA sequence and is hence probably also involved in its own transcription activation (PubMed:21057008, PubMed:21775428, PubMed:24646934). The recognition sequence is 5'-WHGAWNH-N(3-5)-WHGAWNH-3', where W is A/T, H is C/A/T, N is G/C/A/T and the linker length in the middle is 3 to 5 nucleotides (PubMed:21057008).^[1] ^[2] ^[3]

References

↑ Hickey JM, Weldon L, Hefty PS. The atypical OmpR/PhoB response regulator ChxR from Chlamydia trachomatis forms homodimers in vivo and binds a direct repeat of nucleotide sequences. J Bacteriol. 2011 Jan;193(2):389-98. PMID:21057008 doi:10.1128/JB.00833-10
↑ Hickey JM, Lovell S, Battaile KP, Hu L, Middaugh CR, Hefty PS. The atypical response regulator protein ChxR has structural characteristics and dimer interface interactions that are unique within the OmpR/PhoB subfamily. J Biol Chem. 2011 Sep 16;286(37):32606-16. Epub 2011 Jul 20. PMID:21775428 doi:10.1074/jbc.M111.220574
↑ Barta ML, Hickey JM, Anbanandam A, Dyer K, Hammel M, Hefty PS. Atypical response regulator ChxR from Chlamydia trachomatis is structurally poised for DNA binding. PLoS One. 2014 Mar 19;9(3):e91760. doi: 10.1371/journal.pone.0091760. eCollection, 2014. PMID:24646934 doi:http://dx.doi.org/10.1371/journal.pone.0091760

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OCA

[1] Hickey JM, Weldon L, Hefty PS. The atypical OmpR/PhoB response regulator ChxR from Chlamydia trachomatis forms homodimers in vivo and binds a direct repeat of nucleotide sequences. J Bacteriol. 2011 Jan;193(2):389-98. PMID:21057008 doi:10.1128/JB.00833-10

[2] Hickey JM, Lovell S, Battaile KP, Hu L, Middaugh CR, Hefty PS. The atypical response regulator protein ChxR has structural characteristics and dimer interface interactions that are unique within the OmpR/PhoB subfamily. J Biol Chem. 2011 Sep 16;286(37):32606-16. Epub 2011 Jul 20. PMID:21775428 doi:10.1074/jbc.M111.220574

[3] Barta ML, Hickey JM, Anbanandam A, Dyer K, Hammel M, Hefty PS. Atypical response regulator ChxR from Chlamydia trachomatis is structurally poised for DNA binding. PLoS One. 2014 Mar 19;9(3):e91760. doi: 10.1371/journal.pone.0091760. eCollection, 2014. PMID:24646934 doi:http://dx.doi.org/10.1371/journal.pone.0091760

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