3lz6

Guinea Pig 11beta hydroxysteroid dehydrogenase with PF-877423Guinea Pig 11beta hydroxysteroid dehydrogenase with PF-877423

Structural highlights

3lz6 is a 4 chain structure with sequence from Cavia porcellus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.84Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DHI1_CAVPO Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).^[1]

References

↑ Pu X, Yang K. Guinea pig 11beta-hydroxysteroid dehydrogenase type 1: primary structure and catalytic properties. Steroids. 2000 Mar;65(3):148-56. PMID:10699594

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OCA

[1] Pu X, Yang K. Guinea pig 11beta-hydroxysteroid dehydrogenase type 1: primary structure and catalytic properties. Steroids. 2000 Mar;65(3):148-56. PMID:10699594

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