Crystal structure of Reston ebolavirus VP35 RNA binding domainCrystal structure of Reston ebolavirus VP35 RNA binding domain
Structural highlights
3ks4 is a 2 chain structure with sequence from Reston ebolavirus - Reston. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
VP35_EBORR Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
