3h0x

Crystal structure of peptide-binding domain of Kar2 protein from Saccharomyces cerevisiaeCrystal structure of peptide-binding domain of Kar2 protein from Saccharomyces cerevisiae

Structural highlights

3h0x is a 1 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.92Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

BIP_YEAST Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Kimura T, Hosoda Y, Sato Y, Kitamura Y, Ikeda T, Horibe T, Kikuchi M. Interactions among yeast protein-disulfide isomerase proteins and endoplasmic reticulum chaperone proteins influence their activities. J Biol Chem. 2005 Sep 9;280(36):31438-41. Epub 2005 Jul 7. PMID:16002399 doi:http://dx.doi.org/10.1074/jbc.M503377200

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OCA

[1] Kimura T, Hosoda Y, Sato Y, Kitamura Y, Ikeda T, Horibe T, Kikuchi M. Interactions among yeast protein-disulfide isomerase proteins and endoplasmic reticulum chaperone proteins influence their activities. J Biol Chem. 2005 Sep 9;280(36):31438-41. Epub 2005 Jul 7. PMID:16002399 doi:http://dx.doi.org/10.1074/jbc.M503377200

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