Xray structure of scorpion toxin BmBKTx1Xray structure of scorpion toxin BmBKTx1

Structural highlights

3e8y is a 1 chain structure with sequence from Mesobuthus martensii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.1Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KA191_MESMA Selective inhibitor of high conductance calcium-activated potassium channels KCa1.1/KCNMA1. May be insect specific.[1] [PDB:3E8Y]

Publication Abstract from PubMed

Racemic protein crystallography, enabled by total chemical synthesis, has allowed us to determine the X-ray structure of native scorpion toxin BmBKTx1; direct methods were used for phase determination. This is the first example of a protein racemate that crystallized in space group I41/a.

X-ray structure of native scorpion toxin BmBKTx1 by racemic protein crystallography using direct methods.,Mandal K, Pentelute BL, Tereshko V, Kossiakoff AA, Kent SB J Am Chem Soc. 2009 Feb 4;131(4):1362-3. PMID:19133782[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. Xu CQ, Brone B, Wicher D, Bozkurt O, Lu WY, Huys I, Han YH, Tytgat J, Van Kerkhove E, Chi CW. BmBKTx1, a novel Ca2+-activated K+ channel blocker purified from the Asian scorpion Buthus martensi Karsch. J Biol Chem. 2004 Aug 13;279(33):34562-9. Epub 2004 Jun 3. PMID:15178692 doi:http://dx.doi.org/10.1074/jbc.M312798200
  2. Mandal K, Pentelute BL, Tereshko V, Kossiakoff AA, Kent SB. X-ray structure of native scorpion toxin BmBKTx1 by racemic protein crystallography using direct methods. J Am Chem Soc. 2009 Feb 4;131(4):1362-3. PMID:19133782 doi:10.1021/ja8077973

3e8y, resolution 1.10Å

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