Contribution of all 20 amino acids at site 96 to the stability and structure of T4 lysozymeContribution of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme
Structural highlights
3c8q is a 1 chain structure with sequence from Escherichia virus T4. This structure supersedes the now removed PDB entry 2nzb. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
ENLYS_BPT4 Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
↑Moussa SH, Kuznetsov V, Tran TA, Sacchettini JC, Young R. Protein determinants of phage T4 lysis inhibition. Protein Sci. 2012 Apr;21(4):571-82. doi: 10.1002/pro.2042. Epub 2012 Mar 2. PMID:22389108 doi:http://dx.doi.org/10.1002/pro.2042