Crystal structure of L-talarate/galactarate dehydratase from Salmonella typhimurium LT2Crystal structure of L-talarate/galactarate dehydratase from Salmonella typhimurium LT2

Structural highlights

2pp0 is a 3 chain structure with sequence from Salmonella enterica subsp. enterica serovar Typhimurium. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TAGAD_SALTY Catalyzes the efficient dehydration of both L-talarate and galactarate to 5-keto-4-deoxy-D-glucarate. Also catalyzes the epimerization of L-talarate to galactarate; epimerization occurs in competition with dehydration. Is required for the utilization of L-talarate as a carbon source. Also functions in galactarate utilization. Is not active on other acid sugars.[1]

Evolutionary Conservation

 

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. Yew WS, Fedorov AA, Fedorov EV, Almo SC, Gerlt JA. Evolution of enzymatic activities in the enolase superfamily: L-talarate/galactarate dehydratase from Salmonella typhimurium LT2. Biochemistry. 2007 Aug 21;46(33):9564-77. Epub 2007 Jul 25. PMID:17649980 doi:10.1021/bi7008882

2pp0, resolution 2.20Å

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