2mie

Solution structure of the CLAVATA encoded peptide of Arabidopsis thaliana - AtCLE44Solution structure of the CLAVATA encoded peptide of Arabidopsis thaliana - AtCLE44

Structural highlights

2mie is a 1 chain structure with sequence from Arabidopsis thaliana. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CLE41_ARATH Extracellular signal peptide that regulates cell fate. May act with TDR as a ligand-receptor pair in a signal transduction pathway that represses tracheary element differentiation but promotes the formation of procambial cells adjacent to phloem cells in the veins in an auxin-dependent manner.^[1] ^[2] ^[3]

References

↑ Ito Y, Nakanomyo I, Motose H, Iwamoto K, Sawa S, Dohmae N, Fukuda H. Dodeca-CLE peptides as suppressors of plant stem cell differentiation. Science. 2006 Aug 11;313(5788):842-5. PMID:16902140 doi:http://dx.doi.org/10.1126/science.1128436
↑ Hirakawa Y, Shinohara H, Kondo Y, Inoue A, Nakanomyo I, Ogawa M, Sawa S, Ohashi-Ito K, Matsubayashi Y, Fukuda H. Non-cell-autonomous control of vascular stem cell fate by a CLE peptide/receptor system. Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15208-13. doi:, 10.1073/pnas.0808444105. Epub 2008 Sep 23. PMID:18812507 doi:http://dx.doi.org/10.1073/pnas.0808444105
↑ Whitford R, Fernandez A, De Groodt R, Ortega E, Hilson P. Plant CLE peptides from two distinct functional classes synergistically induce division of vascular cells. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18625-30. doi:, 10.1073/pnas.0809395105. Epub 2008 Nov 14. PMID:19011104 doi:http://dx.doi.org/10.1073/pnas.0809395105

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OCA

[1] Ito Y, Nakanomyo I, Motose H, Iwamoto K, Sawa S, Dohmae N, Fukuda H. Dodeca-CLE peptides as suppressors of plant stem cell differentiation. Science. 2006 Aug 11;313(5788):842-5. PMID:16902140 doi:http://dx.doi.org/10.1126/science.1128436

[2] Hirakawa Y, Shinohara H, Kondo Y, Inoue A, Nakanomyo I, Ogawa M, Sawa S, Ohashi-Ito K, Matsubayashi Y, Fukuda H. Non-cell-autonomous control of vascular stem cell fate by a CLE peptide/receptor system. Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15208-13. doi:, 10.1073/pnas.0808444105. Epub 2008 Sep 23. PMID:18812507 doi:http://dx.doi.org/10.1073/pnas.0808444105

[3] Whitford R, Fernandez A, De Groodt R, Ortega E, Hilson P. Plant CLE peptides from two distinct functional classes synergistically induce division of vascular cells. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18625-30. doi:, 10.1073/pnas.0809395105. Epub 2008 Nov 14. PMID:19011104 doi:http://dx.doi.org/10.1073/pnas.0809395105

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