2m6o

The actinobacterial transcription factor RbpA binds to the principal sigma subunit of RNA polymeraseThe actinobacterial transcription factor RbpA binds to the principal sigma subunit of RNA polymerase

Structural highlights

2m6o is a 1 chain structure with sequence from Streptomyces coelicolor A3(2). Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RBPA_STRCO Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Stimulates transcription from several principal sigma factor HrdB (SigA)-dependent promoters but not from a SigR-dependent promoter. Stimulation occurs in the presence of the transcription initiation inhibitor rifampicin (Rif).[HAMAP-Rule:MF_01483]^[1] ^[2]

References

↑ Newell KV, Thomas DP, Brekasis D, Paget MS. The RNA polymerase-binding protein RbpA confers basal levels of rifampicin resistance on Streptomyces coelicolor. Mol Microbiol. 2006 May;60(3):687-96. PMID:16629670 doi:10.1111/j.1365-2958.2006.05116.x
↑ Tabib-Salazar A, Liu B, Doughty P, Lewis RA, Ghosh S, Parsy ML, Simpson PJ, O'Dwyer K, Matthews SJ, Paget MS. The actinobacterial transcription factor RbpA binds to the principal sigma subunit of RNA polymerase. Nucleic Acids Res. 2013 Apr 19. PMID:23605043 doi:10.1093/nar/gkt277

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OCA

[1] Newell KV, Thomas DP, Brekasis D, Paget MS. The RNA polymerase-binding protein RbpA confers basal levels of rifampicin resistance on Streptomyces coelicolor. Mol Microbiol. 2006 May;60(3):687-96. PMID:16629670 doi:10.1111/j.1365-2958.2006.05116.x

[2] Tabib-Salazar A, Liu B, Doughty P, Lewis RA, Ghosh S, Parsy ML, Simpson PJ, O'Dwyer K, Matthews SJ, Paget MS. The actinobacterial transcription factor RbpA binds to the principal sigma subunit of RNA polymerase. Nucleic Acids Res. 2013 Apr 19. PMID:23605043 doi:10.1093/nar/gkt277

[1]

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