NMR solution structure of ALG13 --- obtained with iterative CS-Rosetta from backbone NMR data.NMR solution structure of ALG13 --- obtained with iterative CS-Rosetta from backbone NMR data.

Structural highlights

2ks6 is a 1 chain structure with sequence from Saccharomyces cerevisiae. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ALG13_YEAST Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.[1] [2]

References

  1. Chantret I, Dancourt J, Barbat A, Moore SE. Two proteins homologous to the N- and C-terminal domains of the bacterial glycosyltransferase Murg are required for the second step of dolichyl-linked oligosaccharide synthesis in Saccharomyces cerevisiae. J Biol Chem. 2005 Mar 11;280(10):9236-42. Epub 2004 Dec 22. PMID:15615718 doi:http://dx.doi.org/M413941200
  2. Gao XD, Tachikawa H, Sato T, Jigami Y, Dean N. Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation. J Biol Chem. 2005 Oct 28;280(43):36254-62. Epub 2005 Aug 12. PMID:16100110 doi:http://dx.doi.org/M507569200
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