Solution structure of the second homeobox domain of AT-binding transcription factor 1 (ATBF1)Solution structure of the second homeobox domain of AT-binding transcription factor 1 (ATBF1)
Structural highlights
2da2 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
ZFHX3_HUMAN Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down-regulates the MUC5AC promoter in gastric cancer.[1][2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
↑Berry FB, Miura Y, Mihara K, Kaspar P, Sakata N, Hashimoto-Tamaoki T, Tamaoki T. Positive and negative regulation of myogenic differentiation of C2C12 cells by isoforms of the multiple homeodomain zinc finger transcription factor ATBF1. J Biol Chem. 2001 Jul 6;276(27):25057-65. Epub 2001 Apr 18. PMID:11312261 doi:http://dx.doi.org/10.1074/jbc.M010378200
↑Mori Y, Kataoka H, Miura Y, Kawaguchi M, Kubota E, Ogasawara N, Oshima T, Tanida S, Sasaki M, Ohara H, Mizoshita T, Tatematsu M, Asai K, Joh T. Subcellular localization of ATBF1 regulates MUC5AC transcription in gastric cancer. Int J Cancer. 2007 Jul 15;121(2):241-7. PMID:17330845 doi:http://dx.doi.org/10.1002/ijc.22654
