2d4a

Structure of the malate dehydrogenase from Aeropyrum pernixStructure of the malate dehydrogenase from Aeropyrum pernix

Structural highlights

2d4a is a 4 chain structure with sequence from Aeropyrum pernix. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.87Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MDH_AERPE Catalyzes the reversible oxidation of malate to oxaloacetate. Can also oxidize tartrate. Can utilize both NAD and NADP. Has a preference for NADP.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Kawakami R, Sakuraba H, Goda S, Tsuge H, Ohshima T. Refolding, characterization and crystal structure of (S)-malate dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix. Biochim Biophys Acta. 2009 Oct;1794(10):1496-504. Epub 2009 Jun 23. PMID:19555779 doi:10.1016/j.bbapap.2009.06.014

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OCA

[1] Kawakami R, Sakuraba H, Goda S, Tsuge H, Ohshima T. Refolding, characterization and crystal structure of (S)-malate dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix. Biochim Biophys Acta. 2009 Oct;1794(10):1496-504. Epub 2009 Jun 23. PMID:19555779 doi:10.1016/j.bbapap.2009.06.014

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