Crystal structure of human Zeta-Crystallin with bound NADPCrystal structure of human Zeta-Crystallin with bound NADP
Structural highlights
1yb5 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
QOR_HUMAN Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.[1][2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
↑Fernandez MR, Porte S, Crosas E, Barbera N, Farres J, Biosca JA, Pares X. Human and yeast zeta-crystallins bind AU-rich elements in RNA. Cell Mol Life Sci. 2007 Jun;64(11):1419-27. PMID:17497241 doi:http://dx.doi.org/10.1007/s00018-007-7091-1
↑Lapucci A, Lulli M, Amedei A, Papucci L, Witort E, Di Gesualdo F, Bertolini F, Brewer G, Nicolin A, Bevilacqua A, Schiavone N, Morello D, Donnini M, Capaccioli S. zeta-Crystallin is a bcl-2 mRNA binding protein involved in bcl-2 overexpression in T-cell acute lymphocytic leukemia. FASEB J. 2010 Jun;24(6):1852-65. doi: 10.1096/fj.09-140459. Epub 2010 Jan 26. PMID:20103721 doi:http://dx.doi.org/10.1096/fj.09-140459
