1ya0

Crystal structure of the N-terminal domain of human SMG7Crystal structure of the N-terminal domain of human SMG7

Structural highlights

1ya0 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.55Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SMG7_HUMAN Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Unterholzner L, Izaurralde E. SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. Mol Cell. 2004 Nov 19;16(4):587-96. PMID:15546618 doi:http://dx.doi.org/10.1016/j.molcel.2004.10.013
↑ Fukuhara N, Ebert J, Unterholzner L, Lindner D, Izaurralde E, Conti E. SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. Mol Cell. 2005 Feb 18;17(4):537-47. PMID:15721257 doi:10.1016/j.molcel.2005.01.010

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OCA

[1] Unterholzner L, Izaurralde E. SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. Mol Cell. 2004 Nov 19;16(4):587-96. PMID:15546618 doi:http://dx.doi.org/10.1016/j.molcel.2004.10.013

[2] Fukuhara N, Ebert J, Unterholzner L, Lindner D, Izaurralde E, Conti E. SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. Mol Cell. 2005 Feb 18;17(4):537-47. PMID:15721257 doi:10.1016/j.molcel.2005.01.010

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