Crystal structure of LpdA (Rv3303c) from Mycobacterium tuberculosisCrystal structure of LpdA (Rv3303c) from Mycobacterium tuberculosis
Structural highlights
1xdi is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
LPDA_MYCTU May contribute to virulence by increasing resistance to reactive oxygen intermediates. It can reduce 2,6-dimethyl-1,4-benzoquinone (DMBQ), 5-hydroxy-1,4-naphthaquinone (5-HNQ) and menadione. NADPH is the physiological reductant rather than NADH.[1][2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
↑Argyrou A, Vetting MW, Blanchard JS. Characterization of a new member of the flavoprotein disulfide reductase family of enzymes from Mycobacterium tuberculosis. J Biol Chem. 2004 Dec 10;279(50):52694-702. Epub 2004 Sep 29. PMID:15456792 doi:http://dx.doi.org/10.1074/jbc.M410704200
↑Akhtar P, Srivastava S, Srivastava A, Srivastava M, Srivastava BS, Srivastava R. Rv3303c of Mycobacterium tuberculosis protects tubercle bacilli against oxidative stress in vivo and contributes to virulence in mice. Microbes Infect. 2006 Nov-Dec;8(14-15):2855-62. PMID:17097323 doi:10.1016/j.micinf.2006.09.004
