1x68

Solution structures of the C-terminal LIM domain of human FHL5 proteinSolution structures of the C-terminal LIM domain of human FHL5 protein

Structural highlights

1x68 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

FHL5_HUMAN May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Palermo I, Litrico L, Emmanuele G, Giuffrida V, Sassone-Corsi P, De Cesare D, Maria Fimia G, D'Agata R, Calogero AE, Travali S. Cloning and expression of activator of CREM in testis in human testicular tissue. Biochem Biophys Res Commun. 2001 May 4;283(2):406-11. PMID:11327716 doi:http://dx.doi.org/10.1006/bbrc.2001.4805

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OCA

[1] Palermo I, Litrico L, Emmanuele G, Giuffrida V, Sassone-Corsi P, De Cesare D, Maria Fimia G, D'Agata R, Calogero AE, Travali S. Cloning and expression of activator of CREM in testis in human testicular tissue. Biochem Biophys Res Commun. 2001 May 4;283(2):406-11. PMID:11327716 doi:http://dx.doi.org/10.1006/bbrc.2001.4805

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