1w4r

Structure of a type II thymidine kinase with bound dTTPStructure of a type II thymidine kinase with bound dTTP

Structural highlights 1w4r is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.83Å Ligands: , , Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function KITH_HUMAN Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The structure of human cytosolic thymidine kinase in complex with its feedback inhibitor 2'-deoxythymidine-5'-triphosphate was determined. This structure is the first representative of the type II thymidine kinases found in several pathogens. The structure deviates strongly from the known structures of type I thymidine kinases such as the Herpes simplex enzyme. It contains a zinc-binding domain with four cysteines complexing a structural zinc ion. Interestingly, the backbone atoms of the type II enzyme bind thymine via hydrogen-bonds, in contrast to type I, where side chains are involved. This results in a specificity difference exploited for antiviral therapy. The presented structure will foster the development of new drugs and prodrugs for numerous therapeutic applications. Structure of a type II thymidine kinase with bound dTTP.,Birringer MS, Claus MT, Folkers G, Kloer DP, Schulz GE, Scapozza L FEBS Lett. 2005 Feb 28;579(6):1376-82. PMID:15733844 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Thymidine kinase 3D structures

spinqualitylabelsall models 1w4r, resolution 1.83Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image